Yesterday, the U.S. military dropped the largest non-nuclear bomb in history against ISIS, killing 36 ISIS militants. It was dropped in eastern Afghanistan and was designed to destroy the caves and tunnels in that area, most likely where the "training quarters" are located. Precautions were taken to ensure that civilians were not harmed (there have been no civilian causalities reported). There is also a video included in the article to show the effect of the weapon.
I think it will be interesting to continue to follow the events that follow this strike - how ISIS responds, and what further steps the U.S. will then take. This non-nuclear bomb has also never been used up until this point, so it will be interesting to see what comes from this as well. Will it be a weapon utilized in the future, or just for this event alone, given that it was specifically designed for this strike? While many ISIS members were taken out by this bomb, there are still other members, so now we are in a period of waiting.